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| CAS:152074-97-0:Dirucotide | |
| Dirucotide (MBP 8298) is a native 17-mer peptide fragment of human myelin basic protein, corresponding to the MBP amino acid sequence 83-99. It induces immune tolerance in myelin-specific autoreactive T cells, reduces autoimmune attack on central nervous system myelin, and delays the progression of multiple sclerosis. Applied in autoimmune demyelinating diseases, immune tolerance mechanism and peptide vaccine research. | |
| 95% / 98% / 99% | |
| Native myelin protein-derived linear 17-mer peptide, no chemical modification | |
| ~1960 |
| Function Tags (comma-separated) | N-terminal Modification | C-terminal Modification | |||||||
| Dirucotide; MBP 8298; Myelin basic protein peptide; CAS 152074-97-0 | Aspartic acid-glutamic acid-asparagine-proline-valine-valine-histidine-phenylalanine-phenylalanine-lysine-asparagine-isoleucine-valine-threonine-proline-arginine-threonine | Large polypeptide, no precise small-molecule formula; subject to actual batch MS | - | ~1960 (theoretical) | 17 |
| Long-term Storage Conditions | Short-term Storage Conditions | ||||
| PEP-DRC001 | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Solid powder stable for 1 year at 2-8℃ sealed & dry; prepare aqueous solutions freshly before use | Stable for 48 h at 4℃; stable for 2 weeks at -20℃ in aliquots. **Good water solubility, freely soluble in water and physiological buffer**. Unmodified native long peptide easily degraded by peptidases with rapid activity decay at room temperature. Histidine and tyrosine prone to photooxidation | Stable for 2 years at -20℃ under dry & dark conditions |
| Applicable Research Areas (comma-separated) | ||||
| PEP-DRC001 | Native myelin basic protein 17-mer peptide that induces autoimmune tolerance and delays demyelination progression in multiple sclerosis | Dirucotide is a native T cell epitope peptide derived from human myelin basic protein (MBP), corresponding to the immunodominant epitope at positions 83-99 of the MBP molecule. After uptake by antigen-presenting cells, it is presented to autoreactive CD4+ T cells via MHC class II molecules, inducing T cell anergy, apoptosis or conversion to regulatory T cells, establishing immune tolerance to myelin antigens, thereby reducing T cell-mediated central nervous system myelin damage and demyelinating lesions, and delaying the progression of multiple sclerosis. This peptide is a native endogenous protein fragment with mild immunogenicity and no obvious toxic side effects. It serves as a core tool molecule for multiple sclerosis immunotherapy research, autoimmune tolerance mechanism analysis, myelin antigen epitope identification, and peptide vaccine SAR optimization. | MHC class II molecule-peptide complex; Myelin-specific autoreactive T cells; Central immune tolerance regulatory pathway |
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