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| CAS:142569‑99‑1:IRL‑1620 | |
| IRL‑1620 is a peptide tool drug structurally optimized based on the C‑terminal fragment of endothelin‑1. It binds and activates endothelin B (ETB) receptors with high selectivity, with very low affinity for ETA receptors and no significant agonistic activity. After activating ETB receptors on vascular endothelial cells, it induces the release of nitric oxide and prostacyclin, producing vasodilatory effects; meanwhile, it participates in physiological processes such as neuroprotection, renal blood flow regulation, and cell proliferation regulation. Due to its clear subtype selectivity, it is a core tool peptide for distinguishing endothelin receptor subtype functions and studying the physiological and pathological roles of ETB receptors. | |
| 95%/98%/99% | |
| ~2700 (subject to actual synthetic batch) | |
| Function Tags (comma-separated) | ||||||||
| IRL-1620 | IRL-1620; ETB selective agonist | Endothelin-1 C-terminal fragment backbone with site substitution and N-terminal modification for optimized subtype selectivity | - | ~2700 (theoretical) | N-terminal succinylation + amino acid site substitution |
| Long-term Storage | Short-term Storage | ||||
| PEP-IRL001 | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 2 weeks at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 7 days at 4℃; slowly degraded by peptidases at room temperature**Moderate water solubility, soluble in neutral or weakly alkaline buffer, decreased solubility under acidic conditions**. Stability better than native endothelin fragment after modification | Stable for 2 years at -20℃ under dry & dark conditions |
| Applicable Research Areas (comma-separated) | ||||
| PEP-IRL001 | IRL-1620 specifically binds G protein-coupled ETB receptors, activates downstream signaling pathways, and mediates various biological effects: acts on vascular endothelial cells, induces nitric oxide synthase activation and nitric oxide release, produces endothelium-dependent vasodilation and reduces peripheral resistance; acts on the nervous system, promotes neurogenesis and reduces ischemic nerve injury, exerting neuroprotective effects; regulates renal blood flow and water-sodium excretion, participating in renal function regulation. It has extremely weak affinity for ETA receptors and no obvious vasoconstrictive effect, can specifically distinguish the physiological and pathological functions of ET receptor subtypes, and is the gold standard tool peptide for endothelin system research. |
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